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Review
. 2006 Apr;8(4):1151-6.
doi: 10.1016/j.micinf.2005.10.030. Epub 2006 Jan 19.

Lessons learned from molecular defects in nuclear factor kappaB dependent signaling

Douglas R McDonald  1 , Riny Janssen, Raif Geha
Affiliations
Free article
Review

Lessons learned from molecular defects in nuclear factor kappaB dependent signaling

Douglas R McDonald et al. Microbes Infect. 2006 Apr.
Free article

Abstract

Nuclear factor (NF) kappaB is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NFkappaB, complemented by mouse knockout models, has demonstrated the vital role of NFkappaB in normal host defense.

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