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Comparative Study
. 2006 Jan-Feb;29(1):15-7.
doi: 10.1097/00002826-200601000-00005.

Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study

Eitan Auriel  1 , Jeffrey M Hausdorff, Talia Herman, Ely S Simon, Nir Giladi
Affiliations
Comparative Study

Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study

Eitan Auriel et al. Clin Neuropharmacol. 2006 Jan-Feb.

Abstract

Twenty-one patients with Parkinson's disease were studied before and 2 h after the administration of a single dose of 20 mg of methylphenidate. In response to methylphenidate, attention significantly improved, whereas memory and visual-spatial performance were unchanged. Gait speed, stride time variability, and Timed Up and Go times (demonstrated measures of fall risk) significantly improved. These findings suggest a new potential pharmacologic means of enhancing mobility and decreasing fall risk in Parkinson's disease.

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