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. 1991 Jun;104(6):494-7.

A serological study of hepatitis C infection in plasmapheresis donors

Z D Meng  1 , Y D Sun, X R Chen, S Y Wang, D G Sun, Z Chen, C B Liu, H Zhuang, Z Y Xu
Affiliations
  • PMID: 1651830

A serological study of hepatitis C infection in plasmapheresis donors

Z D Meng et al. Chin Med J (Engl). 1991 Jun.

Abstract

An epidemic of parenterally transmitted non-A, non-B hepatitis (PT-NANBH) occurred in plasmapheresis donors in Guan County, Hebei Province, China, in 1985. PT-NANBH was diagnosed by epidemiological studies and serological exclusion of HAV, HBV, CMV and EBV infections. Recently, 163 sera samples of 108 patients with PT-NANBH and 65 sera samples of 49 cases with elevated alanine aminotransferase (ALT) levels collected during the epidemic were tested by anti-HCV EIA (Chiron C100). The positive rates of anti-HCV in these two groups were 89.8% (97/108) and 93.9% (46/49), averaging 90.8%. The figures increased with the course of illness and persistance of ALT elevation, i.e., 17.6% and 55.6% within 1 month, 88.9% and 87.5% at 6 months and 100% and 100% after 2 years. Five patients with PT-NANBH and 1 with elevated ALT levels were followed up for 3 to 4 years. We demonstrated that anti-HCV remained positive after the disease had resolved and ALT levels had normalized.

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