Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Jul 20;25(31):4257-66.
doi: 10.1038/sj.onc.1209456. Epub 2006 Mar 6.

Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

D Ribatti  1 , B Nico, A Vacca
Affiliations
Review

Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

D Ribatti et al. Oncogene. .

Abstract

Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.

PubMed Disclaimer

Publication types