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Review
. 2006 Apr;8(4):1141-50.
doi: 10.1016/j.micinf.2005.10.028. Epub 2006 Jan 19.

Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity

Rainer Doffinger  1 , Smita Y Patel, Dinakantha S Kumararatne
Affiliations
Free article
Review

Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity

Rainer Doffinger et al. Microbes Infect. 2006 Apr.
Free article

Abstract

This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.

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