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. 2006 Feb;68(2):179-82.
doi: 10.1292/jvms.68.179.

Infectivity of porcine circovirus 1 and circovirus 2 in primary porcine hepatocyte and kidney cell cultures

Takuya Hirai  1 , Tetsuo Nunoya, Takeshi Ihara, Toshiki Saitoh, Kazumoto Shibuya, Keigo Nakamura
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Free article

Infectivity of porcine circovirus 1 and circovirus 2 in primary porcine hepatocyte and kidney cell cultures

Takuya Hirai et al. J Vet Med Sci. 2006 Feb.
Free article

Abstract

Infectivity of porcine circovirus (PCV) 1 and PCV2 was examined in primary porcine hepatocyte culture by comparing that of PCV in primary kidney cell culture. The virus titer of PCV2-infected hepatocyte cultures was higher than that of the PCV1-infected hepatocyte cultures and the PCV-infected kidney cell cultures. The number of virus-positive cells was most abundant in PCV2-infected hepatocyte cultures as determined by immunohistochemistry and/or in situ hybridization. The results of our data suggest that PCV2 preferably infects cultured hepatocytes as observed in the liver of pigs with postweaning multisystemic wasting syndrome.

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