Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Mar 1;22(3):235-40.
doi: 10.1016/s0828-282x(06)70903-5.

Overview of recent advances in molecular cardiology

Zhongjie Sun  1
Affiliations
Review

Overview of recent advances in molecular cardiology

Zhongjie Sun. Can J Cardiol. .

Abstract
in English, French

Molecular cardiology is a new and fast-growing area of cardiovascular medicine that aims to apply molecular biology techniques for the mechanistic investigation, diagnosis, prevention and treatment of cardiovascular disease. As an emerging discipline, it has changed conceptual thinking of cardiovascular development, disease etiology and pathophysiology. Although molecular cardiology is still at a very early stage, it has opened a promising avenue for understanding and controlling cardiovascular disease. With the rapid development and application of molecular biology techniques, scientists and clinicians are closer to curing heart diseases that were thought to be incurable 20 years ago. There clearly is a need for a more thorough understanding of the molecular mechanisms of cardiovascular diseases to promote the advancement of stem cell therapy and gene therapy for heart diseases. The present paper briefly reviews the state-of-the-art techniques in the following areas of molecular cardiology: gene analysis in the diseased heart; transgenic techniques in cardiac research; gene transfer and gene therapy for cardiovascular disease; and stem cell therapy for cardiovascular disease.

La cardiologie moléculaire est un nouveau domaine en forte expansion de la médecine cardiovasculaire, qui vise à appliquer les techniques de biologie moléculaire aux explorations mécanistes, au diagnostic, à la prévention et au traitement des maladies cardiovasculaires. Cette discipline émergente a modifié la pensée conceptuelle du développement cardiovasculaire ainsi que de l’étiologie et de la physiopathologie des maladies. Bien que la cardiologie moléculaire soit encore à un stade très précoce, elle a ouvert des voies prometteuses pour comprendre et contrôler les maladies cardiovasculaires. Grâce au développement et à l’application rapides des techniques de biologie moléculaire, les scientifiques et les cliniciens se rapprochent de la guérison de maladies cardiaques qu’on croyait incurables il y a 20 ans. De toute évidence, il faut comprendre les mécanismes moléculaires des maladies cardiaques de manière plus approfondie pour promouvoir la progression de la thérapie des cellules souches et de la thérapie génique dans les maladies cardiaques. Le présent article analyse brièvement les techniques de pointe dans certains domaines de la cardiologie moléculaire: analyse génétique du cœur malade, techniques transgéniques en recherche cardiaque, transfert et thérapie géniques ainsi que thérapie des cellules souches en présence de maladies cardiovasculaires.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Sun Z, Cade JR, Fregly MJ, Rowland NE. Effect of chronic treatment with propranolol on the cardiovascular responses to chronic cold exposure. Physiol Behav. 1997;62:379–84. - PubMed
    1. Sun Z, Cade R, Zhang Z, Alouidor J, Van H. Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension. 2003;41:322–7. - PubMed
    1. Rajamanickam C, Jeejabai R. Delineation of sequences essential for specific promoter activation during pressure overload hypertrophy of factor-induced hypertrophy. In: Sun Z, editor. Molecular Cardiology: Methods and Protocols. Totowa: Humana Press; 2005. pp. 251–60. - PubMed
    1. Rajamanickam C, Jeejabai R. Evaluation of the cardiac isoform of alpha2-macroglobulin as a factor inducing cardiac hypertrophy. In: Sun Z, editor. Molecular Cardiology: Methods and Protocols. Totowa: Humana Press; 2005. pp. 261–76. - PubMed
    1. Barbosa ME, Alenina N, Bader M. Induction and analysis of cardiac hypertrophy in transgenic animal models. In: Sun Z, editor. Molecular Cardiology: Methods and Protocols. Totowa: Humana Press; 2005. pp. 339–52. - PubMed

Publication types