Dynamics of intramolecular recognition: base-pairing in DNA/RNA near and far from equilibrium
- PMID: 16520899
- DOI: 10.1140/epje/i2005-10061-3
Dynamics of intramolecular recognition: base-pairing in DNA/RNA near and far from equilibrium
Abstract
The physics of the base-pairing interaction in DNA and RNA molecules plays a fundamental role in biology. Past experimental and theoretical research has led to a fairly complete and quantitative understanding of the equilibrium properties such as the different phases, the melting behavior, and the response to slow stretching. The non-equilibrium behavior is even richer than might be expected on the basis of thermodynamics. However, the non-equilibrium behavior is also far less understood. Here, we review different theoretical approaches to the study of base-pairing thermodynamics and kinetics, and illustrate the rich phenomenology with several examples that use these approaches.
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