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. 1991;42(5):252-6.
doi: 10.1159/000138805.

cAMP and vascular action of endothelin

M C Yang  1 , M S Tu, C K Chou, C Y Hong, J S Kuo
Affiliations

cAMP and vascular action of endothelin

M C Yang et al. Pharmacology. 1991.

Abstract

Endothelin, a potent vasoconstricting peptide, induced maximal contraction of the rat tail artery within 3 min of administration. Endothelin also caused a dose-dependent decrease in tissue levels of cAMP. Concentrations of cAMP decreased about 60% 1 min after endothelin (10(-8) M) administration, but returned to basal levels in 5 min. By contrast, tissue levels of cGMP were not changed by endothelin. Modulation of cAMP production may provide one mechanism for the vascular action of endothelin.

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