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. 1975 Feb;55(2):431-5.
doi: 10.1172/JCI107948.

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes

J A Sandler, R I Clyman, V C Manganiello, M Vaughan

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes

J A Sandler et al. J Clin Invest. 1975 Feb.

Abstract

The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...

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