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. 1991 Mar;12(2):243-8.
doi: 10.1016/0142-9612(91)90207-q.

In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh

M L Cooper  1 , J F Hansbrough, R L Spielvogel, R Cohen, R L Bartel, G Naughton
Affiliations

In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh

M L Cooper et al. Biomaterials. 1991 Mar.

Abstract

The design of a skin-substitute must address the need for a dermal component, as this mesenchymally-derived tissue is important in maintaining the integrity and function of skin. An in vivo study was undertaken to assess the use of two biodegradable meshes, polyglycolic acid and polyglactin-910, as carriers for cultured human fibroblasts in a living dermal replacement. The consistent vascularization and epithelialization of these grafts placed on athymic mice showed that this has potential in re-creating the dermis in a skin-substitute.

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