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. 2006 Mar 16;8(6):1125-8.
doi: 10.1021/ol0531381.

An improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol

Ralf J Kloetzing  1 , Tobias Thaler, Paul Knochel
Affiliations

An improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol

Ralf J Kloetzing et al. Org Lett. .

Abstract

[reaction: see text] (-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.

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