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Editorial
. 2006 Mar;4(3):e87.
doi: 10.1371/journal.pbio.0040087. Epub 2006 Mar 14.

Being positive about selection

Catriona MacCallum, Emma Hill
Editorial

Being positive about selection

Catriona MacCallum et al. PLoS Biol. 2006 Mar.

Abstract

Detecting positive selection at the molecular level has recently become easier and editors of PLoS Biology face the challenge of identifying standards of excellence in the face of burgeoning interest in this field.

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Figures

Figure 1
Figure 1. The Increasing Interest in Articles Detecting Positive Selection, as Reflected in the Number of Citations (y-Axis) to Some Key Methodological Papers, from Their Publication until the End of 2005
(A) McDonald and Keitman (1991) [1], (B) Nielsen and Yang (1998) [3], and (C) Yang (1997) [4]. Please note that not all articles citing these papers focus only on detecting positive selection. For example, citations to Yang (1997) [4] are to PAML, a computer program that implements many methods in addition to calculating K a /K s ratios. Data collated from ISI Web of Knowledge (Science Citation Expanded) on 17 January 2006.
See this image and copyright information in PMC

Comment on

References

    1. McDonald JH, Kreitman M. Adaptive protein evolution at the Adh locus in Drosophila. Nature. 1991;351:652–654. - PubMed
    1. Hurst LD. The Ka/Ks ratio: Diagnosing the form of sequence evolution. Trends Genet. 2002;18:486. - PubMed
    1. Nielsen R, Yang Z. Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene. Genetics. 1998;148:929–936. - PMC - PubMed
    1. Yang Z. PAML: A program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci. 1997;13:555–556. - PubMed
    1. Chamary JV, Parmley JL, Hurst LD. Hearing silence: Non-neutral evolution at synonymous sites in mammals. Nat Rev Genet. 2006;7:98–108. - PubMed