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Comparative Study
. 1991 Aug 5;287(1-2):211-4.
doi: 10.1016/0014-5793(91)80053-6.

Site-directed mutagenesis of La protease. A catalytically active serine residue

Amerik AYu  1 , V K Antonov, A E Gorbalenya, S A Kotova, T V Rotanova, E V Shimbarevich
Affiliations
Free article
Comparative Study

Site-directed mutagenesis of La protease. A catalytically active serine residue

Amerik AYu et al. FEBS Lett. .
Free article

Abstract

Comparative sequence analysis of Escherichia coli ATP-dependent La protease led to the suggestion that Ser679 is the catalytically active enzyme residue. Site-directed mutagenesis Ser679----Ala, investigation of the cells containing the mutant plasmid, and study of the partially purified mutant protein produced results in favour of this suggestion.

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