[The oxygen supply of brain tissue under decreased oxygen tension in the capillary arterial blood]

Abstract

Using mathematical model describing the oxygen transport in the brain three-dimensional microarea, the regularities of oxygen diffusion were studied in conditions of reduced oxygen content in the blood flowing through capillaries. Considering ordinary neuron-capillary spatial relationships and average values of the blood flow in the capillaries and oxygen consumption in neural tissues, the neural cells surrounding the capillaries can only function normally provided the oxygen tension is over 61 mm Hg at the arterial end of the capillaries. However, if the intercapillary distance is reduced, the neural cells have no hypoxia even at the oxygen tension of 40 mm Hg at the arterial and of capillaries.