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Review
. 2006 Mar 8;2006(6):re1.
doi: 10.1126/sageke.2006.6.re1.

The development of amyloid beta protein deposits in the aged brain

Dietmar R Thal  1 , Estibaliz Capetillo-Zarate, Kelly Del Tredici, Heiko Braak
Affiliations
Review

The development of amyloid beta protein deposits in the aged brain

Dietmar R Thal et al. Sci Aging Knowledge Environ. .

Abstract

The deposition of amyloid beta protein (Abeta) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of Abeta takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Abeta production and clearance. This Review describes the different types of Abeta deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Abeta deposition. The role of intracellular Abeta in Abeta deposition and the mechanism of Abeta toxicity are also discussed.

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