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. 1991 Sep;59(9):3316-8.
doi: 10.1128/iai.59.9.3316-3318.1991.

Production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by human neutrophils is inhibited by Pseudomonas aeruginosa phenazine derivatives

M Muller  1 , T C Sorrell
Affiliations

Production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by human neutrophils is inhibited by Pseudomonas aeruginosa phenazine derivatives

M Muller et al. Infect Immun. 1991 Sep.

Abstract

Pyocyanin, a phenazine pigment produced by Pseudomonas aeruginosa, and its metabolite 1-hydroxyphenazine inhibited leukotriene B4 and 5-hydroxyeicosatetraenoic acid production by up to 70% in human neutrophils stimulated with the calcium ionophore A23187 (5 microM). This potential anti-inflammatory effect was dose dependent and occurred at low concentrations (10 to 50 microM) that did not inhibit neutrophil viability.

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References

    1. Can J Biochem Physiol. 1959 Aug;37(8):911-7 - PubMed
    1. Rev Infect Dis. 1984 Sep-Oct;6 Suppl 3:S617-26 - PubMed
    1. Infect Immun. 1990 Mar;58(3):659-66 - PubMed
    1. J Biol Chem. 1984 Aug 25;259(16):10181-7 - PubMed
    1. J Bacteriol. 1980 Jan;141(1):156-63 - PubMed

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