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. 1991 Aug;148(2):191-6.
doi: 10.1002/jcp.1041480202.

Generation of superoxide anion by brain endothelial cell xanthine oxidase

L S Terada  1 , I R Willingham, M E Rosandich, J A Leff, G W Kindt, J E Repine
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Generation of superoxide anion by brain endothelial cell xanthine oxidase

L S Terada et al. J Cell Physiol. 1991 Aug.

Abstract

Bovine brain endothelial cells (EC) that were isolated and propagated in pure culture had increased (greater than 20-fold) levels of xanthine oxidase and xanthine dehydrogenase activity compared to whole brain homogenate. Brain EC also released superoxide anion (O2-) into the extracellular medium. Treatment of EC with tungsten decreased (P less than 0.05) both XO activity and O2- release. XO appears to be highly concentrated in cerebral vascular endothelium and may be an important source of O2-.

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