Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Aug 15;278 ( Pt 1)(Pt 1):43-7.
doi: 10.1042/bj2780043.

Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

B H Davis  1 , U R Rapp, N O Davidson
Affiliations

Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

B H Davis et al. Biochem J. .

Abstract

Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor beta (TGF beta) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGF beta blocked PDGF-induced cell proliferation. TGF beta, but not retinoic acid, diminished PDGF-receptor and smooth-muscle alpha-actin abundance.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1989 Mar 6;1010(3):318-24 - PubMed
    1. Liver. 1983 Feb;3(1):58-63 - PubMed
    1. Cell Tissue Kinet. 1989 Sep;22(5):393-9 - PubMed
    1. J Cell Biol. 1989 Jul;109(1):429-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1558-62 - PubMed

Publication types