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. 2006 Mar 10;124(5):883-5.
doi: 10.1016/j.cell.2006.02.028.

The Notch transcription activation complex makes its move

Doug Barrick  1 , Raphael Kopan
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The Notch transcription activation complex makes its move

Doug Barrick et al. Cell. .
Free article

Abstract

Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.

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