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Comment
. 2006 Mar 10;124(5):886-8.
doi: 10.1016/j.cell.2006.02.026.

A long-distance relationship between RNAi and Polycomb

Elissa P Lei  1 , Victor G Corces
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A long-distance relationship between RNAi and Polycomb

Elissa P Lei et al. Cell. .
Free article

Abstract

RNA interference (RNAi) pathways can result in sequence-specific transcriptional gene silencing on the level of chromatin. In this issue of Cell, Grimaud et al. (2006) reveal that the RNAi machinery is required for long-distance physical interactions between chromosomes mediated by the Polycomb repressive complex. These results suggest that the RNAi machinery may regulate higher-order nuclear organization.

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