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. 2006 Mar 10;124(5):888-90.
doi: 10.1016/j.cell.2006.02.029.

TOPping up ATR activity

Jiri Bartek  1 , Niels Mailand
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Free article
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TOPping up ATR activity

Jiri Bartek et al. Cell. .
Free article

Abstract

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

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