Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Mar 10;124(5):893-5.
doi: 10.1016/j.cell.2006.02.031.

TGF-beta regulation by Emilin1: new links in the etiology of hypertension

Malavika Raman  1 , Melanie H Cobb
Affiliations
Comment

TGF-beta regulation by Emilin1: new links in the etiology of hypertension

Malavika Raman et al. Cell. .

Abstract

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.

PubMed Disclaimer

Comment on

  • Emilin1 links TGF-beta maturation to blood pressure homeostasis.
    Zacchigna L, Vecchione C, Notte A, Cordenonsi M, Dupont S, Maretto S, Cifelli G, Ferrari A, Maffei A, Fabbro C, Braghetta P, Marino G, Selvetella G, Aretini A, Colonnese C, Bettarini U, Russo G, Soligo S, Adorno M, Bonaldo P, Volpin D, Piccolo S, Lembo G, Bressan GM. Zacchigna L, et al. Cell. 2006 Mar 10;124(5):929-42. doi: 10.1016/j.cell.2005.12.035. Cell. 2006. PMID: 16530041

Substances