Review
doi: 10.1016/j.tem.2006.02.006.
Epub 2006 Mar 10.
The use of mifepristone in the treatment of neuropsychiatric disorders
Affiliations
- PMID: 16530421
- DOI: 10.1016/j.tem.2006.02.006
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Review
The use of mifepristone in the treatment of neuropsychiatric disorders
Trends Endocrinol Metab.
2006 Apr.
Erratum in
- Trends Endocrinol Metab. 2006 Dec;17(10):389
Abstract
Mifepristone is a potent glucocorticoid and progesterone receptor antagonist. The pathophysiology of a number of neuropsychiatric disorders implicates abnormalities in glucocorticoid function. These include mood disorders such as psychotic major depression and bipolar depression. In addition, cognitive disorders such as Alzheimer's disease might also be partially mediated by abnormalities in the hypothalamic-pituitary-adrenal axis. Preliminary studies suggest that mifepristone might have a role in the treatment of a number of neuropsychiatric disorders.
Comment in
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Claims for mifepristone in neuropsychiatric disorders: commentary on DeBattista and Belanoff, and Neigh and Nemeroff.Trends Endocrinol Metab. 2006 Dec;17(10):384-5; author reply 387-9. doi: 10.1016/j.tem.2006.10.009. Epub 2006 Oct 27. Trends Endocrinol Metab. 2006. PMID: 17070696 No abstract available.
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Financial disclosure.Trends Endocrinol Metab. 2006 Dec;17(10):380. Trends Endocrinol Metab. 2006. PMID: 17252626 No abstract available.
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