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Review
. 2006 Apr;17(3):117-21.
doi: 10.1016/j.tem.2006.02.006. Epub 2006 Mar 10.

The use of mifepristone in the treatment of neuropsychiatric disorders

Charles DeBattista  1 , Joseph Belanoff
Affiliations
Review

The use of mifepristone in the treatment of neuropsychiatric disorders

Charles DeBattista et al. Trends Endocrinol Metab. 2006 Apr.

Erratum in

  • Trends Endocrinol Metab. 2006 Dec;17(10):389

Abstract

Mifepristone is a potent glucocorticoid and progesterone receptor antagonist. The pathophysiology of a number of neuropsychiatric disorders implicates abnormalities in glucocorticoid function. These include mood disorders such as psychotic major depression and bipolar depression. In addition, cognitive disorders such as Alzheimer's disease might also be partially mediated by abnormalities in the hypothalamic-pituitary-adrenal axis. Preliminary studies suggest that mifepristone might have a role in the treatment of a number of neuropsychiatric disorders.

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