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Case Reports
. 2006 Jan-Mar;5(1):56-9.

Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis

V Byrnes  1 , N Afdhal, T Challies, P E Greenstein
Affiliations
  • PMID: 16531969
Free article
Case Reports

Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis

V Byrnes et al. Ann Hepatol. 2006 Jan-Mar.
Free article

Abstract

Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity. Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta. We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.

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