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. 2006 Oct;30(10):1273-8.
doi: 10.1016/j.leukres.2006.02.002. Epub 2006 Mar 14.

Expression of the cell cycle regulators p14(ARF) and p16(INK4a) in chronic myeloid leukemia

Marie Cividin  1 , Olivier Ayrault, Nathalie Sorel, Paule Séité, Françoise Brizard, Odile Blanchet, François-Xavier Mahon, François Guilhot, Christian Larsen, Jean-Claude Chomel, André Brizard
Affiliations

Expression of the cell cycle regulators p14(ARF) and p16(INK4a) in chronic myeloid leukemia

Marie Cividin et al. Leuk Res. 2006 Oct.

Abstract

Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML). The p14(ARF) and p16(INK4a) mRNA levels were significantly low in patients in chronic phase (CP) at presentation and high in patients treated with interferon-alpha (IFN-alpha), especially in non-responders. A moderate overexpression of p14(ARF) with a normal expression of p16(INK4a) was observed in imatinib-resistant patients. Although protein expression did not consistently match mRNA levels, a role for the two cell cycle regulators in the IFN-alpha signaling pathway is suggested as well as a relation with the resistance to IFN-alpha or imatinib therapy.

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