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Clinical Trial
. 2006 Mar 14;66(5):742-4.
doi: 10.1212/01.wnl.0000201193.00382.b3.

High-dose rituximab and anti-MAG-associated polyneuropathy

S Renaud  1 , P Fuhr, M Gregor, K Schweikert, D Lorenz, C Daniels, G Deuschl, A Gratwohl, A J Steck
Affiliations
Clinical Trial

High-dose rituximab and anti-MAG-associated polyneuropathy

S Renaud et al. Neurology. .

Abstract

Rituximab has been administered successfully in patients with polyneuropathy associated with antibodies to myelin-associated glycoprotein (anti-MAG). The authors present a follow-up study with high-dose rituximab. Increase of rituximab from 375 mg/m2 to a dose of 750 mg/m2 was well tolerated and led to clinical improvement in four of eight patients, along with improvement of nerve conduction velocities and a reduction of anti-MAG antibody titers.

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