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Comparative Study
. 1991 Oct;184(2):781-5.
doi: 10.1016/0042-6822(91)90452-h.

Molecular cloning, sequence analysis and coding assignment of the major inner capsid protein gene of human group C rotavirus

S J Cooke  1 , P R Lambden, E O Caul, I N Clarke
Affiliations
Comparative Study

Molecular cloning, sequence analysis and coding assignment of the major inner capsid protein gene of human group C rotavirus

S J Cooke et al. Virology. 1991 Oct.

Abstract

The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The protein sequence demonstrated low homology with the group A VP6 sequences (41.7 to 42.7%) and high homology (88.9%) with the porcine group C VP6 sequence. However, the protein sequence alignments revealed a region of 10 amino acids that were significantly different between the human and the porcine group C viruses.

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