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Comment
. 2006 Jan;4(1):e24.
doi: 10.1371/journal.pbio.0040024.

The "Ets" factor: vessel formation in zebrafish--the missing link?

Lucy J Patterson  1 , Roger Patient
Affiliations
Comment

The "Ets" factor: vessel formation in zebrafish--the missing link?

Lucy J Patterson et al. PLoS Biol. 2006 Jan.

Abstract

The zebrafish offers a powerful model for studying the development of new blood vessels.

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Figures

Figure 1
Figure 1. The Fine Detail of the Developing Vasculature of an approximately four-day-old Zebrafish Embryo Is Revealed Using Confocal Microangiography
The accessibility and optical clarity of zebrafish embryos lend a particular advantage to the study of vascular development. Fluorescent microspheres can be injected into the blood stream, penetrating the entire patent vascular system, allowing imaging of the vasculature using confocal microscopy. (Photo: B. Weinstein)
Figure 2
Figure 2. The Haemangioblast
Many lines of evidence support the notion that blood and endothelium share a common precursor, the haemangioblast. EC, endothelial cell; Hmgb, haemangioblast; HSC, haematopoietic stem cell.
Figure 3
Figure 3. A Putative Model for the Regulation of Haemangioblast Specification and Differentiation in the Zebrafish Posterior Lateral Plate Mesoderm
Cloche acts to specify the haemangioblast and is required for the expression of both scl and etsrp [5,29]. Scl is essential for the initiation of GATA1 expression and for all subsequent haematopoietic development [30]. Although endothelial cells are formed in the absence of Scl, flk1 expression is reduced from the outset, culminating in the failure of dorsal aorta specification [30]. Conversely, Etsrp is essential for flk1 expression and for elaboration of the endothelial programme.
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References

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