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. 2006 Jan;67(1):5-13.
doi: 10.15288/jsa.2006.67.5.

Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior

William R Corbin  1 , Kim Fromme, Susan E Bergeson
Affiliations

Preliminary data on the association among the serotonin transporter polymorphism, subjective alcohol experiences, and drinking behavior

William R Corbin et al. J Stud Alcohol. 2006 Jan.

Abstract

Objective: Individual differences in subjective responses to alcohol are believed to have a genetic basis and have been associated with increased risk of alcohol-related problems. There are, however, conflicting results from past studies, perhaps owing to differences in subjective alcohol effects by limb of the blood alcohol curve and the passage of time. The current pilot study evaluated relations among serotonin transporter (SERT) genotype, subjective alcohol responses, and drinking behavior across both the ascending and descending limbs of the blood alcohol curve.

Method: Participants (N=222; 68% male) were administered alcohol (target blood alcohol concentration of .06%) with a subsample (n=86) providing genetic data. Following a social stressor, participants were provided the opportunity to engage in ad libitum alcohol consumption.

Results: SERT transporter was not significantly associated with ad lib drinking or subjective alcohol effects at individual time points, although a trend toward a SERT by blood alcohol concentration limb interaction was observed for ad lib drinking. In addition, SERT genotype predicted acute tolerance to alcohol effects, with participants homozygous for the long SERT allele developing acute tolerance more rapidly than other genotypes.

Conclusions: Although SERT genotype was not reliably associated with ad lib drinking behavior, the results suggest that individuals with the long-long (LL) genotype may develop acute tolerance to alcohol effects more rapidly than heterozygotes or individuals homozygous for the short SERT allele.

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Figures

Figure 1
Figure 1
Change in subjective intoxication over time by serotonin transporter (SERT) genotype
Figure 2
Figure 2
Changes in subjective high over time by serotonin transporter (SERT) genotype
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References

    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) Washington, DC: 1987.
    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Washington, DC: 1994.
    1. Campbell JID, Thompson VA. More power to you: Simple power calculations for treatment effects with one degree of freedom. Behav. Res. Meth. Instr. Comput. 2002;34:332–337. - PubMed
    1. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd Edition Lawrence Erlbaum; Mahwah, NJ: 1998.
    1. Collins RL, Parks GA, Marlatt GA. Social determinants of alcohol consumption: The effects of social interaction and model status on the self-administration of alcohol. J. Cons. Clin. Psychol. 1985;53:189–200. - PubMed

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