Review
doi: 10.1016/j.exger.2006.01.011.
Epub 2006 Mar 14.
Connexin 43 and ischemic preconditioning: effects of age and disease
Affiliations
- PMID: 16537100
- DOI: 10.1016/j.exger.2006.01.011
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Review
Connexin 43 and ischemic preconditioning: effects of age and disease
Exp Gerontol.
2006 May.
Abstract
Connexin 43 (Cx43) is the constitutive protein for the formation of cardiac gap junctions and therefore essential for cell-cell coupling and normal cardiac function. Apart from its localization at the sarcolemma, Cx43 is present in the inner mitochondrial membrane. Cx43 is involved in cardiomyocyte free oxygen radical formation and in the cardioprotection by ischemic preconditioning (IP). This review will discuss Cx43 deficiency in aged and diseased myocardium and the potential impact of age and disease on IP's cardioprotection.
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