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. 2006 Mar;16(2):64-70.
doi: 10.2188/jea.16.64.

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren

Chie Fujii  1 , Hisataka Sakakibara, Takaaki Kondo, Hiroshi Yatsuya, Koji Tamakoshi, Hideaki Toyoshima
Affiliations

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren

Chie Fujii et al. J Epidemiol. 2006 Mar.

Abstract

Background: Plasma fibrinogen level has been recognized as an independent risk factor for atherosclerosis and its thrombotic complications in adults. The present study aimed to clarify the association between plasma fibrinogen levels and cardiovascular risk factors in Japanese children.

Methods: A total of 294 schoolchildren (145 boys and 149 girls) aged 10-13 years in a town in Nagano Prefecture, Japan, were surveyed in 2000 for body mass index (BMI), plasma fibrinogen, serum C-reactive protein (CRP), serum total cholesterol, serum high-density lipoprotein (HDL) cholesterol, hemoglobin (Hb) A1c, and ratio of serum total cholesterol to serum HDL cholesterol (TCHR).

Results: The mean value and standard deviation of plasma fibrinogen level among the schoolchildren was 226.0+/-39.7 mg/dL for boys and 245.3+/-40.9 mg/dL for girls; significantly higher for girls. Among plasma fibrinogen tertiles, serum CRP tended to increase with plasma fibrinogen in both boys and girls. An increasing trend was also found in serum total cholesterol in boys, and in TCHR, HbA1c and BMI in girls. Multiple linear regression analysis revealed significant associations of plasma fibrinogen with serum CRP and HbA1c in both sexes, with TCHR in boys, and with BMI in girls.

Conclusions: Plasma fibrinogen levels were associated with cardiovascular risk factors such as serum CRP, TCHR, HbA1c, and BMI in Japanese schoolchildren.

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Figures

Figure 1.
Figure 1.. Distribution of plasma fibrinogen concentration among Japanese schoolchildren.
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References

    1. Imperatore G, Riccardi G, Iovine C, Rivellese AA, Vaccaro O. Plasma fibrinogen: a new factor of the metabolic syndrome. A population-based study. Diabet Care 1998; 21: 649-54. - PubMed
    1. Tracy RP, Arnold AM, Ettinger W, Fried L, Meilahn E, Savage P. The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly: results from the cardiovascular health study. Arterioscler Thromb Vasc Biol 1999; 19: 1776-83. - PubMed
    1. Ford ES. The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count:findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis 2003; 168: 351-8. - PubMed
    1. Kristensen B, Malm J, Nilsson TK, Hultdin J, Carlberg B, Olsson T. Increased fibrinogen levels and acquired hypofibrinolysis in young adults with ischemic stroke. Stroke 1998; 29: 2261-7 - PubMed
    1. Ernst E, Resch KL. Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 1993; 118: 956-63. - PubMed

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