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. 1991 Aug;64(2):227-32.
doi: 10.1038/bjc.1991.281.

Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples

S Gledhill  1 , A Gallagher, D B Jones, A S Krajewski, F E Alexander, E Klee, D H Wright, C O'Brien, D E Onions, R F Jarrett
Affiliations
Free PMC article

Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples

S Gledhill et al. Br J Cancer. 1991 Aug.
Free PMC article

Abstract

Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.

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References

    1. J Virol. 1987 May;61(5):1310-7 - PubMed
    1. Eur J Immunol. 1987 Aug;17(8):1199-207 - PubMed
    1. Science. 1986 Oct 31;234(4776):601-3 - PubMed
    1. J Pathol. 1987 Mar;151(3):185-90 - PubMed
    1. Lancet. 1989 Sep 30;2(8666):761-5 - PubMed

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