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. 2006 Apr;185(3):389-94.
doi: 10.1007/s00213-006-0329-z. Epub 2006 Mar 16.

Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology

Jacqueline Borg  1 , Bengt Andrée, Johan Lundberg, Christer Halldin, Lars Farde
Affiliations

Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology

Jacqueline Borg et al. Psychopharmacology (Berl). 2006 Apr.

Abstract

Rationale: Animal studies and studies of human aging have suggested that the serotonin 5-HT1A receptor may serve as a biomarker for cognitive functioning and a target for pharmacological treatment of cognitive deficits.

Objectives: The purpose of this positron emission tomography (PET) study was to search for relationships between interindividual variability in serotonin 5-HT1A receptor binding potential (BP) and cognitive functioning.

Materials and methods: Twenty-four male control subjects, age 20-55 years, were examined with [11C]WAY100635 PET and a battery of cognitive tests. 5-HT1A receptor binding potential were calculated for the raphe nuclei, the hippocampus and the neocortex. Correlation coefficients between BP and cognitive performance were obtained for each region.

Results: There was a severalfold of variability in 5-HT1A BP between individuals. We found no significant correlation between regional [11C]WAY100635 binding and cognitive performance.

Conclusions: The results do not provide support for involvement of the 5-HT1A receptor in cognitive functioning in man and question the predictive validity of some currently used animal models in translational neuroscience.

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References

    1. Am J Psychiatry. 2003 Feb;160(2):334-40 - PubMed
    1. Am J Psychiatry. 2001 Oct;158(10):1722-5 - PubMed
    1. Am J Psychiatry. 2000 Apr;157(4):635-7 - PubMed
    1. Neurobiol Learn Mem. 1999 Mar;71(2):207-18 - PubMed
    1. Arch Clin Neuropsychol. 1989;4(1):15-24 - PubMed

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