HLA-DRB1 genes and extraarticular rheumatoid arthritis
- PMID: 16542468
- PMCID: PMC1526581
- DOI: 10.1186/ar1886
HLA-DRB1 genes and extraarticular rheumatoid arthritis
Abstract
The factors that trigger the development of extraarticular features of rheumatoid arthritis (RA) are still unknown. HLA-DR alleles such as HLA-DR4 and HLA-DR1 are associated with the risk to develop RA. A large scale study from Sweden and the Mayo Clinic suggests that HLA-DR4, but not HLA-DR1, is associated with the risk to develop extraarticular RA.
Comment on
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The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis.Arthritis Res Ther. 2005;7(6):R1386-93. doi: 10.1186/ar1837. Epub 2005 Oct 11. Arthritis Res Ther. 2005. PMID: 16277691 Free PMC article.
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