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Editorial
. 2006;8(1):103.
doi: 10.1186/ar1886. Epub 2006 Jan 12.

HLA-DRB1 genes and extraarticular rheumatoid arthritis

Affiliations
Editorial

HLA-DRB1 genes and extraarticular rheumatoid arthritis

Jean Roudier. Arthritis Res Ther. 2006.

Abstract

The factors that trigger the development of extraarticular features of rheumatoid arthritis (RA) are still unknown. HLA-DR alleles such as HLA-DR4 and HLA-DR1 are associated with the risk to develop RA. A large scale study from Sweden and the Mayo Clinic suggests that HLA-DR4, but not HLA-DR1, is associated with the risk to develop extraarticular RA.

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References

    1. Turesson C, Schaid DJ, Weyand CM, Jacobsson LTH, Goronzy JJ, Petersson IF, Sturfelt G, Nyhäll-Wåhlin BM, Truedsson L, Dechant SA, Matteson EL. The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. Arthritis Res Ther. 2005;7:R1386–R1393. doi: 10.1186/ar1837. - DOI - PMC - PubMed
    1. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 1987;30:1205–1213. - PubMed
    1. Reviron D, Perdriger A, Toussirot E, Wendling D, Balandraud N, Guis S, Semama G, Tiberghien P, Mercier P, Roudier J. Influence of shared epitope negative alleles on genetic susceptibility to rheumatoid arthritis. Arthritis Rheum. 2001;44:535–540. doi: 10.1002/1529-0131(200103)44:3<535::AID-ANR101>3.0.CO;2-Z. - DOI - PubMed
    1. Benazet JF, Reviron D, Mercier P, Roux H, Roudier J. HLA-DRB1 alleles associated with rheumatoid arthritis in southern France. Absence of extraarticular disease despite expression of the shared epitope. J Rheumatol. 1995;22:607–610. - PubMed
    1. Gorman JD, David-Vaudey E, Pai M, Lum R, Criswell LA. Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis. Arthritis Rheum. 2004;50:3476–3484. doi: 10.1002/art.20588. - DOI - PubMed

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