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Review
. 2006;10(2):126.
doi: 10.1186/cc4842.

Levels of protein C and activated protein C: what do they mean?

Affiliations
Review

Levels of protein C and activated protein C: what do they mean?

Jan A Hazelzet. Crit Care. 2006.

Abstract

Acute pancreatitis is a local inflammatory process that leads to a systemic inflammatory response in the majority of cases, and sometimes leads to multiple organ failure. It is obvious that coagulation and especially the protein C system are involved in this disease. The present commentary is related to a study in patients with pancreatitis with and without multiple organ failure in which protein C and activated protein C levels were studied. The protein C system and other studies analyzing (activated) protein C levels are discussed.

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References

    1. Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J. Up-regulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe pancreatitis. Crit Care. 2006;10:R16. doi: 10.1186/cc3966. - DOI - PMC - PubMed
    1. Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas. 2004;47:305–314. doi: 10.1016/j.maturitas.2003.10.015. - DOI - PubMed
    1. Hermans PW, Hazelzet JA. Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. Clin Infect Dis. 2005;41(Suppl 7):S453–S458. doi: 10.1086/431996. - DOI - PubMed
    1. Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res. 2005 - PubMed
    1. Iba T, Kidokoro A, Fukunaga M, Sugiyama K, Sawada T, Kato H. Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers. Shock. 2005;23:25–29. doi: 10.1097/01.shk.0000144422.32647.b6. - DOI - PubMed

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