Levels of protein C and activated protein C: what do they mean?
- PMID: 16542498
- PMCID: PMC1550916
- DOI: 10.1186/cc4842
Levels of protein C and activated protein C: what do they mean?
Abstract
Acute pancreatitis is a local inflammatory process that leads to a systemic inflammatory response in the majority of cases, and sometimes leads to multiple organ failure. It is obvious that coagulation and especially the protein C system are involved in this disease. The present commentary is related to a study in patients with pancreatitis with and without multiple organ failure in which protein C and activated protein C levels were studied. The protein C system and other studies analyzing (activated) protein C levels are discussed.
Comment on
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Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis.Crit Care. 2006 Feb;10(1):R16. doi: 10.1186/cc3966. Crit Care. 2006. PMID: 16420659 Free PMC article.
References
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- Lindstrom O, Kylanpaa L, Mentula P, Puolakkainen P, Kemppainen E, Haapiainen R, Fernandez JA, Griffin JH, Repo H, Petaja J. Up-regulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe pancreatitis. Crit Care. 2006;10:R16. doi: 10.1186/cc3966. - DOI - PMC - PubMed
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- Zeerleder S, Schroeder V, Hack CE, Kohler HP, Wuillemin WA. TAFI and PAI-1 levels in human sepsis. Thromb Res. 2005 - PubMed
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