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. 1975 May 1;255(5503):33-7.
doi: 10.1038/255033a0.

5'-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation

S Muthukrishnan, G W Both, Y Furuichi, A J Shatkin

5'-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation

S Muthukrishnan et al. Nature. .

Abstract

Unmethylated reovirus and VSV mRNAs are specifically methylated to form 5'-terminal structures of the type, m-7-G(5')ppp(5')N by protein synthesising extracts prepared from wheat germ and mouse L cells. Reticulocyte mRNA also contains 5'-terminal m-7-G. MRNAs having 5'-terminal m-7-G stimulate protein synthesis in vitro. Removal of m-7-G by beta-elimination abolishes translation of the mRNAs.

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