Review
doi: 10.1016/j.molcel.2006.03.005.
Growth factor withdrawal and apoptosis: the middle game
Affiliations
- PMID: 16543140
- DOI: 10.1016/j.molcel.2006.03.005
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Review
Growth factor withdrawal and apoptosis: the middle game
Mol Cell.
.
Free article
Abstract
In this issue of Molecular Cell, detail molecular events that trigger apoptosis following growth factor withdrawal, linking irreversible mitochondrial permeabilization to activation of GSK-3 and subsequent phosphorylation, ubiquitinylation, and degradation of the antiapoptotic BCL-2 family member MCL-1.
Comment on
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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.Mol Cell. 2006 Mar 17;21(6):749-60. doi: 10.1016/j.molcel.2006.02.009. Mol Cell. 2006. PMID: 16543145
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