Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Apr;77(4):525-8.
doi: 10.1136/jnnp.2005.075325.

Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration

Affiliations
Case Reports

Cerebellar hypermetabolism in paraneoplastic cerebellar degeneration

K-D Choi et al. J Neurol Neurosurg Psychiatry. 2006 Apr.

Abstract

A 51 year old man with paraneoplastic cerebellar degeneration from gastric adenocarcinoma showed cerebellar hypermetabolism and increased perfusion on brain FDG-PET scan and SPECT during the acute stage of his illness. The patient underwent subtotal gastrectomy. The intensity of the hypermetabolism had decreased markedly on follow-up FDG-PET 3 months later following two cycles of chemotherapy. We suggest that the cerebellar hypermetabolism may have been due to an acute inflammatory process associated with an immunological reaction.

PubMed Disclaimer

Conflict of interest statement

Competing interests: none declared

Comment in

References

    1. Shams'ili S, Grefkens J, de Leeuw B.et al Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 20031261409–1418. - PubMed
    1. Dalmau J O, Posner J B. Paraneoplastic syndromes. Arch Neurol 199956405–408. - PubMed
    1. Scheid R, Lincke T, Voltz R.et al Serial 18F‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis. Arch Neurol 2004611785–1789. - PubMed
    1. Kassubek J, Juengling F D, Nitzsche E U.et al Limbic encephalitis investigated by 18FDG‐PET and 3D MRI. J Neuroimaging 20011155–59. - PubMed
    1. Meglic B, Graus F, Grad A. Anti‐Yo‐associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma. J Neurol Sci 2001185135–138. - PubMed

Publication types

MeSH terms

Substances