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Case Reports
. 2006 May;36(1):76-8.
doi: 10.1016/j.jcv.2005.12.012. Epub 2006 Mar 20.

Use of genomic analysis of varicella-zoster virus to investigate suspected varicella-zoster transmission within a renal unit

P J Molyneaux  1 , S Parker, I H Khan, C G M Millar, J Breuer
Affiliations
Case Reports

Use of genomic analysis of varicella-zoster virus to investigate suspected varicella-zoster transmission within a renal unit

P J Molyneaux et al. J Clin Virol. 2006 May.

Abstract

Background: The source of hospital-acquired chickenpox infection may be presumed from a known exposure, but has not been previously proven using genomic analysis.

Objective: Investigation of suspected VZV transmission was done using single nucleotide polymorphism genomic analysis.

Study design: Comparison was made of viral isolates from two patients with chickenpox on the same ward who were not known to have had direct contact.

Results: An identical genotype in the variable R1 region of the VZV was isolated from the two patients.

Conclusion: Inapparent hospital-acquired transmission was the most likely route of infection.

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