doi: 10.1126/science.1654597.
Transcriptional repression mediated by the WT1 Wilms tumor gene product
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- PMID: 1654597
- DOI: 10.1126/science.1654597
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Transcriptional repression mediated by the WT1 Wilms tumor gene product
Science.
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Abstract
The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger-containing protein that binds to the same DNA sequence as EGR-1, a mitogen-inducible immediate-early gene product that activates transcription. The transcriptional regulatory potential of WT1 has not been demonstrated. In transient transfection assays, the WT1 protein functioned as a repressor of transcription when bound to the EGR-1 site. The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor.
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