Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 May;33(1-2):67-70.
doi: 10.1007/BF01993129.

The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells

S Bent  1 , U Fehling, U Braam, W Schunack, W Schmutzler
Affiliations

The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells

S Bent et al. Agents Actions. 1991 May.

Abstract

The effects of the H3-agonist R-alpha-methylhistamine (R-alpha-MeHA) and the H3-antagonist thioperamide on the spontaneous and concanavalin A (ConA) induced histamine release from human mast cells were tested and compared with the effect of some H1- and H2-receptor active substances. R-alpha-MeHA (10(-9)-10(-7) M) exerted no effect on histamine release whereas thioperamide increased the spontaneous release at 10(-6)-10(-4) M but inhibited the ConA induced release in a narrow concentration range (10(-6)-10(-5) M). This enhancement might be taken as an indication of the existence of H3-receptor dependent autoregulation although presently other mechanism cannot be excluded.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Int Arch Allergy Appl Immunol. 1985;77(1-2):177-8 - PubMed
    1. Agents Actions. 1989 Apr;27(1-2):83-5 - PubMed
    1. Br J Pharmacol. 1980 Aug;69(4):663-7 - PubMed
    1. Nature. 1983 Apr 28;302(5911):832-7 - PubMed
    1. Agents Actions. 1990 Apr;30(1-2):121-4 - PubMed

MeSH terms

LinkOut - more resources