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. 2006 Feb;21(1):75-8.
doi: 10.2133/dmpk.21.75.

Novel single nucleotide polymorphism of UGT1A7 gene in Japanese

Ken-ichi Fujita  1 , Yuichi Ando, Fumio Nagashima, Wataru Yamamoto, Hisashi Endo, Keiji Kodama, Kazuhiro Araki, Toshimichi Miya, Masaru Narabayashi, Yasutsuna Sasaki
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Free article

Novel single nucleotide polymorphism of UGT1A7 gene in Japanese

Ken-ichi Fujita et al. Drug Metab Pharmacokinet. 2006 Feb.
Free article

Abstract

We sequenced exon 1 of the UDP-glucuronosyltransferase (UGT) 1A7 gene from 52 Japanese cancer patients. Four single nucleotide polymorphisms (SNPs) were found. Three of them caused UGT1A7*2 and UGT1A7*3. A novel SNP (98973G>C) causing amino acid substitution (Ser141Cys) was found. The sequence is as follows: SNP, 050824FujitaK002; Gene Name, UGT1A7; Accession Number, AF297093; Length, 25 bases; 5'-TAAAGGAGAGTTG/CTTTTGATGCAGT-3'. One out of 52 cancer patients was heterozygous for the variant allele, resulting in the allele frequency of 0.96%. The patient did not possess UGT1A7*2 or UGT1A7*3.

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