Risk factors for development of posttransplant diabetes mellitus in renal transplant recipients
- PMID: 16549166
- DOI: 10.1016/j.transproceed.2005.12.066
Risk factors for development of posttransplant diabetes mellitus in renal transplant recipients
Abstract
Diabetes mellitus appearing after kidney transplantation--posttransplant diabetes mellitus (PTDM)--is a common complication associated with poor graft and patient survival. The purpose of the current study was to determine the risk factors for developing PTDM in 204 renal transplant recipients who had been followed for at least 30 months. Posttransplant diabetes mellitus was diagnosed according to the American Diabetic Association/WHO criteria, or a requirement for insulin, an oral hypoglycemic agent, or both. Analyses of possible risk factors for PTDM included demographic features, dialysis and posttransplantation duration, smoking, body mass index, medications, co-morbid diseases, HLA mismatches, as well as laboratory metrics of serum creatinine, albumin, calcium, phosphorus, C-reactive protein, parathyroid hormone, and lipid profiles. Twenty-six patients displayed PTDM. Univariate analysis showed that older age, greater body mass index, presence of hepatitis C virus (HCV) infection, and smoking at the time of renal transplantation were associated with PTDM development. In a multivariate analysis, HCV infection, smoking, and patient age at the time of transplantation were independent risk factors for PTDM. In conclusion, the presence of HCV infection or a smoking habit in addition to older age at the time of transplantation were the main predictors for developing PTDM. Patients should be closely followed regarding their smoking habit and weight gain as modifiable risk factors for PTDM.
Similar articles
-
Posttransplant diabetes mellitus: Impact of good blood glucose regulation on renal transplant recipient outcome.Transplant Proc. 2006 Mar;38(2):533-6. doi: 10.1016/j.transproceed.2005.12.106. Transplant Proc. 2006. PMID: 16549167
-
Risk factors and incidence of posttransplant diabetes mellitus in renal transplant recipients.Transplant Proc. 2004 Sep;36(7):2139-40. doi: 10.1016/j.transproceed.2004.08.118. Transplant Proc. 2004. PMID: 15518776
-
Posttransplant diabetes mellitus: incidence and risk factors.Transplant Proc. 2009 Sep;41(7):2811-3. doi: 10.1016/j.transproceed.2009.07.043. Transplant Proc. 2009. PMID: 19765442
-
Post-transplant diabetes mellitus.J Nephrol. 2003 Sep-Oct;16(5):626-34. J Nephrol. 2003. PMID: 14733407 Review.
-
[Sugar diabetes after renal transplantation in children].Ann Pediatr (Paris). 1993 Feb;40(2):112-8. Ann Pediatr (Paris). 1993. PMID: 8457131 Review. French.
Cited by
-
Hepatitis C virus and type 2 diabetes.World J Gastroenterol. 2009 Apr 7;15(13):1537-47. doi: 10.3748/wjg.15.1537. World J Gastroenterol. 2009. PMID: 19340895 Free PMC article. Review.
-
Association Between Pre-Transplant Magnesemia and Post-Transplant Dysglycemia in Kidney Transplant Recipients.Int J Endocrinol Metab. 2020 Jan 14;18(1):e97292. doi: 10.5812/ijem.97292. eCollection 2020 Jan. Int J Endocrinol Metab. 2020. PMID: 32308698 Free PMC article.
-
Pre-transplant weight but not weight gain is associated with new-onset diabetes after transplantation: a multi-centre cohort Spanish study.NDT Plus. 2010 Jun;3(Suppl_2):ii15-ii20. doi: 10.1093/ndtplus/sfq065. NDT Plus. 2010. PMID: 20508859 Free PMC article.
-
New-onset diabetes after transplantation in tacrolimus-treated, living kidney transplantation: long-term impact and utility of the pre-transplant OGTT.Int Urol Nephrol. 2010 Dec;42(4):935-45. doi: 10.1007/s11255-010-9712-0. Epub 2010 Feb 19. Int Urol Nephrol. 2010. PMID: 20169408 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials