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. 2006 Apr 4;20(6):939-42.
doi: 10.1097/01.aids.0000218563.12897.ba.

Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes

Livia Pedroza-Martins  1 , W John Boscardin, Deborah J Anisman-Posner, Beverly N Redsar, Yvonne J Bryson, Otto O Yang, Christel H Uittenbogaart
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Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes

Livia Pedroza-Martins et al. AIDS. .

Abstract

As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output.

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