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. 1975 Apr;72(4):1397-400.
doi: 10.1073/pnas.72.4.1397.

Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells

C M Croce, D Aden, H Koprowski

Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells

C M Croce et al. Proc Natl Acad Sci U S A. 1975 Apr.

Abstract

Cells derived from tumors induced in "nude" mice after injection of cells that were hybrids between mouse peritoneal macrophages and simian virus 40 (SV40)-transformed human cells were found to retain the human chromosome 7 carrying the SV40 genome, and indicate that the presence of human chromosome 7 carrying the SV40 genome is responsible for the expression of the tumorigenic phenotype in the hybrid cells.

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References

    1. Lancet. 1971 Oct 30;2(7731):971-2 - PubMed
    1. Virology. 1974 Jul;60(1):276-81 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1268-72 - PubMed
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