Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Aug;103(4):1837-9.
doi: 10.1111/j.1476-5381.1991.tb12337.x.

GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

T G Smart  1 , S J Moss, X Xie, R L Huganir
Affiliations

GABAA receptors are differentially sensitive to zinc: dependence on subunit composition

T G Smart et al. Br J Pharmacol. 1991 Aug.

Abstract

GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma subunit were inhibited by zinc. Embryonic neurons also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the gamma subunit.

PubMed Disclaimer

References

    1. Brain Res Mol Brain Res. 1990 Aug;8(3):199-208 - PubMed
    1. Neuron. 1990 Dec;5(6):781-8 - PubMed
    1. J Neurochem. 1991 Feb;56(2):713-5 - PubMed
    1. J Pharm Pharmacol. 1990 Jun;42(6):377-87 - PubMed
    1. Eur J Pharmacol. 1990 Jul 31;189(1):77-88 - PubMed

Publication types

LinkOut - more resources