doi: 10.1016/0006-8993(91)90099-h.
Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus
Affiliations
- PMID: 1655172
- DOI: 10.1016/0006-8993(91)90099-h
Item in Clipboard
Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus
Brain Res.
.
Abstract
A serotonin (5-HT)-mediated phosphoinositide hydrolysis response was characterized in fibroblasts cultured from rabbit choroid plexus. 5-HT elicited a maximum 8-fold increase in [3H]inositol-phosphate ([3H]IP) formation, while the partial agonists, (+)-lysergic acid diethylamide and (-)-1-(4-bromo-2,5-dimethyoxyphenyl)-2-aminopropane caused 2- and 5-fold increases, respectively. Mianserin, ketanserin, and spiperone were equipotent at blocking the 5-HT-mediated response. Thus, agonist and antagonist profiles indicate interactions with 5-HT2 receptors.
Similar articles
-
Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.J Pharmacol Exp Ther. 1988 Sep;246(3):924-8. J Pharmacol Exp Ther. 1988. PMID: 2843634
-
Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium.J Neurosci. 1992 Dec;12(12):4775-82. doi: 10.1523/JNEUROSCI.12-12-04775.1992. J Neurosci. 1992. PMID: 1334504 Free PMC article.
-
5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor.J Pharmacol Exp Ther. 1990 Jul;254(1):253-7. J Pharmacol Exp Ther. 1990. PMID: 2164094
-
Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD).Neuropsychopharmacology. 1999 Aug;21(2 Suppl):77S-81S. doi: 10.1016/S0893-133X(99)00005-6. Neuropsychopharmacology. 1999. PMID: 10432492 Review.
-
Receptors and phosphoinositide metabolism in the central nervous system.Biochem Pharmacol. 1986 Aug 1;35(15):2447-53. doi: 10.1016/0006-2952(86)90038-9. Biochem Pharmacol. 1986. PMID: 2427081 Review. No abstract available.
Cited by
-
The possible place for psychedelics in pharmacotherapy of mental disorders.Pharmacol Rep. 2023 Dec;75(6):1313-1325. doi: 10.1007/s43440-023-00550-9. Epub 2023 Nov 7. Pharmacol Rep. 2023. PMID: 37934320 Free PMC article. Review.
-
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex.Brain Res. 2013 Jan 23;1491:98-108. doi: 10.1016/j.brainres.2012.10.057. Epub 2012 Nov 1. Brain Res. 2013. PMID: 23123701 Free PMC article.
-
Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter.ACS Chem Neurosci. 2011 Feb 16;2(2):75-81. doi: 10.1021/cn100066p. Epub 2010 Oct 27. ACS Chem Neurosci. 2011. PMID: 22778858 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
