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Review
. 2006 Mar;5(5):512-8.
doi: 10.4161/cc.5.5.2538. Epub 2006 Mar 1.

Akt1 in endothelial cell and angiogenesis

Payaningal R Somanath  1 , Olga V Razorenova, Juhua Chen, Tatiana V Byzova
Affiliations
Review

Akt1 in endothelial cell and angiogenesis

Payaningal R Somanath et al. Cell Cycle. 2006 Mar.

Abstract

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the expression and/or activity of various pro- and anti-angiogenic factors and Akt isoforms (Akt1, Akt2 and Akt3) have been proposed as therapeutic targets for angiogenesis-related anomalies such as cancer and ischemic injury.

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Figures

Figure 1
Figure 1
Phosphorylation of Akt affects multiple substrates. Activation of Akt (phosphorylation on S473 and T308) leads to phosphorylation and activation/inactivation (shown by signs of inhibition and coactivation, respectively) of multiple substrates. Changes in corresponding signaling pathways lead to stimulation of a diverse variety of cellular processes (shown in frames).
Figure 2
Figure 2
Akt1 signaling has both pro- and anti-angiogenic effects. The balance between signaling pathways under different conditions determines the angiogenic phenotype.
See this image and copyright information in PMC

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